Efectos renales y nefroprotección inducidos por el inhibidor del SGLT2 Empagliflozina en pacientes con diabetes mellitus: revisión de la literatura

  • Luis E. Morales-Buenrostro Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Nefrología y Metabolismo Mineral, México D.F.
  • Sonia Citlali Juárez-Comboni Centro de Investigación Clínica Paracelsus, México D.F.
  • Alma Nelly Rodríguez Alcocer Centro de Investigación Clínica Paracelsus, México D.F.

Resumen

La insuficiencia renal es una comorbilidad frecuente en pacientes con diabetes mellitus (DM) e incrementa en ellos el riesgo cardiovascular; la hiperglucemia crónica en pacientes con DM induce una gran cantidad de alteraciones directas e indirectas en la estructura y la función renal, y constituye el principal factor para el desarrollo de la nefropatía diabética y la enfermedad renal terminal. En la presente revisión, se exponen los resultados de los estudios en los que se ha demostrado la alta tolerabilidad de empagliflozina en pacientes diabéticos con insuficiencia renal
concomitante en estadios I a III. Empagliflozina, mediante la inhibición de SGLT2, ofrece una terapia novedosa con efectos benéficos no sólo sobre el control glucémico, sino también beneficios cardiovasculares y renales, los cuales han sido demostrados en el estudio EMPA-REG OUTCOME y continúan en evaluación en otros estudios.

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Publicado
2017-01-01
Cómo citar
1.
Morales-Buenrostro LE, Citlali Juárez-Comboni S, Rodríguez Alcocer AN. Efectos renales y nefroprotección inducidos por el inhibidor del SGLT2 Empagliflozina en pacientes con diabetes mellitus: revisión de la literatura. Rev Nefrol Dial Traspl. [Internet]. 1 de enero de 2017 [citado 29 de marzo de 2024];37(1):48-1. Disponible en: http://www.revistarenal.org.ar/index.php/rndt/article/view/89
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