Evaluación del tabaquismo como factor de riesgo adicional de enfermedades cardiovasculares en pacientes en hemodiálisis según niveles elevados de Il-6, TNFα, hs-CRP y Endotelina-1

  • Hulya Çolak University of Health Sciences, Tepecik Research and Training Hospital, Department of Nephrology, İzmir
  • Şule Cömert Department of Immunology and Allergy, Haydarpaşa Numune Research and Training Hospital, University of Health Sciences, İstanbul
  • Bahar Engin Department of Internal Medicine, Tepecik Research and Training Hospital, University of Health Sciences, İzmir
  • Saliha Aksun Department of Biochemistry, Katip Celebi University, İzmir
  • Sibel Ersan Department of Nephrology, Tepecik Research and Training Hospital, University of Health Sciences, İzmir
  • Papatya Değirmenci Department of Immunology and Allergy, Tepecik Research and Training Hospital, University of Health Sciences, İzmir

Resumen

Introducción: Las enfermedades cardiovasculares (EC) constituyen una de las causas más frecuentes de mortalidad en los casos de enfermedad renal crónica. El tabaquismo es un factor de riesgo bien definido para la enfermedad cardiovascular aterosclerótica. Se encontraron valores elevados de Interleucina-6 (IL-6), factor de necrosis tumoral alfa (TNFα), proteína C-reactiva de alta sensibilidad (hs-CRP) y Endotelina-1 (Et-1) en el proceso inflamatorio crónico. El objetivo fue analizar si los valores de IL-6, TNFα, hs CRP y Et-1 son más elevados en los pacientes fumadores en hemodiálisis que en los no fumadores para predecir una posible enfermedad cardiovascular de forma no invasiva. Material y métodos: Se incluyeron pacientes masculinos en hemodiálisis de mantenimiento, 80 fumadores y 50 no fumadores, similares en cuanto a sus características demográficas, tratamiento de diálisis y de mantenimiento, y perfil metabólico. Además de los análisis de rutina, se tomaron muestras para evaluar los valores de IL-6, TNFα, hs CRP y Endotelina-1. Se midieron los valores de p. Resultados: Se halló una diferencia estadísticamente significativa en los niveles de IL-6, TNFα, hs CRP y Endotelina-1: fueron más elevados en los pacientes sometidos a hemodiálisis que eran fumadores en comparación con los no fumadores. Conclusión: Este estudio podría demostrar que el tabaquismo es un factor de riesgo adicional para los pacientes que se tratan con hemodiálisis según muestran los valores elevados de IL-6, TNFα, hs CRP y Et-1.

 

Cómo citar este artículo:

Hulya Ç, Şule C, Bahar E, Saliha A, Sibel E, Papatya D. [Evaluación del tabaquismo como factor de riesgo adicional de enfermedades cardiovasculares en pacientes en hemodiálisis según niveles elevados de Il-6, TNFα, hs-CRP y Endotelina-1]. Rev Nefrol Dial Traspl. 2018; 38(2):103-10.

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Publicado
2018-07-03
Cómo citar
1.
Çolak H, Cömert Şule, Engin B, Aksun S, Ersan S, Değirmenci P. Evaluación del tabaquismo como factor de riesgo adicional de enfermedades cardiovasculares en pacientes en hemodiálisis según niveles elevados de Il-6, TNFα, hs-CRP y Endotelina-1. Rev Nefrol Dial Traspl. [Internet]. 3 de julio de 2018 [citado 28 de marzo de 2024];38(2):103-10. Disponible en: http://www.revistarenal.org.ar/index.php/rndt/article/view/310
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Artículo Original