Pre-renal hypercreatininemia in an elderly patient: response of a senile kidney to a hypoperfusion state

  • Carlos Guido Musso Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Fernando Alonso Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Griselda Irina Bratti Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Matilde Navarro Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Manuel Vilas Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Federico Varela Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Gustavo Greloni Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
  • Guillermo Rosa Diez Servicio de Nefrología, Hospital Italiano de Buenos Aires, Buenos Aires
Keywords: hypercreatininemia, hypoperfusion, creatinine, elderly, acute renal failure pre-renal

Abstract

Classically, pre-renal acute renal failure is described as a clinical picture characterized by presenting with high uremia and normal creatininemia (pre-renal azotemia). It has also been described in the literature that prerenal renal failure in elderly people (age ≥ 65 years) usually present with high serum values not only of urea (hyperazoemia) but also of creatinine (hypercreatininemia).
In this report, we present the case of an 86-year-old woman who presents with acute renal failure with pre-renal hypercreatininemia and also discusses the pathophysiological basis of this phenomenon.

References

Faber M, Kupin W, Krishna G, Narins R. The differential diagnosis of acute renal failure. En: Lazarus M, Brenner BM, eds. Acute renal failure. 3rd ed. New York : Churchill Livingstone, 1993, pp. 133-84.

Miller TR, Anderson RJ, Linas SL, Henrich WL, Berns AS, Gabow PA, et al. Urinary diagnostic indices in acute renal failure: a prospective study. Ann Intern Med. 1978;89(1):47-50.

Musso CG, Liakopoulos V, Ioannidis I, Eleftheriadis T, Stefanidis I. Acute renal failure in the elderly: particular characteristics. Int Urol Nephrol. 2006;38(3-4):787-93.

Musso CG, Lopez-Novoa JM, Fernandez J, Macías-Núñez JF. Acute renal failure in the aged. En: Macías Núñez JF, Cameron S, Oreopoulos DG, eds. The aging kidney in health and disease. New York: Springer, 2008, pp. 787-93.

Musso CG, Oreopoulos D. Geriatric nephrology. En: Sinclair AJ, Morley JE, Vellas B, eds. Pathy’s principles and practice of geriatric medicine. 5th ed. Chichester, West Sussex: John Wiley & Sons, 2012.

Musso CG, Navarro M. Creatinine: production, diagnostic use and role in renal disease. En: Thorp ML. Handbook of common problems in clinical nephrology. New York: Nova Science Publishers, 2010. (Nephrology research and clinical developments series).

Musso CG. Geriatric nephrology and the "nephrogeriatric giants". Int Urol Nephrol. 2002;34(2):255-6.

Musso CG, Michelángelo H, Vilas M, Reynaldi J, Martinez B, Algranati L, et al. Creatinine reabsorption by the aged kidney. Int Urol Nephrol. 2009;41(3):727-31.

Musso CG, Caceres JM, Peralta M, Luque K, Varela F, Farías E, et al. Fractional excretion of urea in severely dehydrated elderly with dementia. Electron J Biomed. 2005;1:32-5.

Musso CG, Jauregui R, Andresik D, Vilas M, Segalini A, Vazquez C. Sodium and urea urinary saving patterns in the elderly can change according to circumstances. Int Urol Nephrol. 2011;43(2):611-2.

Macías Núñez JF, Musso CG, Rivera H, Imperiali N, Algranati LS. Sodium loss induced hyponatremia in the elderly on a low sodium diet. Electron J Biomed. 2006;2:1-7.

Published
2017-09-06
How to Cite
1.
Musso CG, Alonso F, Bratti GI, Navarro M, Vilas M, Varela F, Greloni G, Rosa Diez G. Pre-renal hypercreatininemia in an elderly patient: response of a senile kidney to a hypoperfusion state. Rev Nefrol Dial Traspl. [Internet]. 2017Sep.6 [cited 2024May18];33(1):48-0. Available from: http://www.revistarenal.org.ar/index.php/rndt/article/view/178
Section
Case Report