Tasa de filtración glomerular medida y estimada. Numerosos métodos de medición (Parte I)

  • Jaime Pérez Loredo Universidad Católica Argentina, Buenos Aires
  • Carlos Alberto Lavorato Universidad Católica Argentina, Buenos Aires
  • Armando Luis Negri Universidad del Salvador, Buenos Aires

Resumen

Una pérdida de la mitad de la masa renal no necesariamente tendrá la mitad de la TFG, es decir, no hay una correlación exacta entre la reducción de masa renal y la pérdida de función renal.
La tasa de filtración glomerular (TFG) es un índice necesario para diagnóstico, seguimiento de pacientes con deterioro de la función renal, chequeos epidemiológicos, ajuste de dosis de drogas nefrotóxicas o de eliminación renal, estadificación de la enfermedad renal crónica, etc.
En esta actualización se analiza brevemente los principales métodos utilizados con el fin de estimar el filtrado glomerular, algunas de sus fortalezas y debilidades. El empleo de la tasa de filtración glomerular estimada en estudios epidemiológicos ha contribuido a generar controversias de envergadura que más que resultar en un avance científico, han producido larguísimas discusiones como producto de sofismas y desvíos por estos cálculos.
Debería replantearse el aplicar ecuaciones de estimación de la TFG en estudios de laboratorio en la población, dada la imperfección de las mismas y a las dificultades en la interpretación de los resultados para el médico clínico no especialista en la materia.

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Publicado
2017-04-22
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1.
Pérez Loredo J, Lavorato CA, Negri AL. Tasa de filtración glomerular medida y estimada. Numerosos métodos de medición (Parte I). Rev Nefrol Dial Traspl. [Internet]. 22 de abril de 2017 [citado 19 de marzo de 2024];35(3):153-64. Disponible en: http://www.revistarenal.org.ar/index.php/rndt/article/view/34
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