Microangiopatía trombótica y lupus erimatoso sistémico

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María Laura Argüello Alegre
Cintia Verónica Marin
Marcelo De Rosa
Fernando Segovia


Paciente de 28 años, Testigo de Jehová, con diagnóstico de lupus eritematoso sistémico con compromiso renal cuatro años antes (nefritis lúpica clase IV con remisión completa). A los 2 años y medio reactiva el compromiso renal y agrega durante la fase de reinducción compromiso hematológico con anemia y plaquetopenia severa, esquistocitos en frotis de sangre periférico, haptoglobina y complemento disminuido.
Se plantea el diagnóstico de microangiopatía trombótica (MAT) de causa primaria versus secundaria. Por cuestiones religiosas se trata la MAT con Rituximab, sumándose posteriormente Eculizumab. No se realizó anatomía patológica renal, ni se realizó plasmaféresis por dicho motivo. Requirió tratamiento dialítico. El ADAMTS XIII era normal y presentaba importante consumo de C3. A los 6 meses de seguimiento, sin actividad lúpica, plaquetopenia ni anemia hemolítica se discontinuó Rituximab y Eculizumab. Continuó en tratamiento dialítico crónico.


Cómo citar este artículo:

Argüello Alegre ML, Marin CV, De Rosa M, Segovia F. Microangiopatía trombótica y lupus erimatoso sistémico. Rev Nefrol Dial Traspl. 2018; 38(2):139-47.

Detalles del artículo

Cómo citar
Argüello Alegre ML, Marin CV, De Rosa M, Segovia F. Microangiopatía trombótica y lupus erimatoso sistémico. Rev Nefrol Dial Traspl. [Internet]. 3 de julio de 2018 [citado 20 de octubre de 2021];38(2):139-47. Disponible en: https://www.revistarenal.org.ar/index.php/rndt/article/view/314


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